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iReceptor+

About Project

Architecture and tools for the query of antibody and T-Cell receptor sequencing data repositories for enabling improved personalized medicine an immunotherapy

iReceptor Plus promotes human immunological data storage, integration and controlled sharing for a wide range of clinical and scientific purposes. The project started in 2019, co-funded by the EU and Canadian government and focused on the development of an innovative platform to integrate distributed repositories of Adaptive Immune Receptor Repertoire sequencing (AIRR-seq) data, to enable improved personalized medicine and immunotherapy in cancer, inflammatory and autoimmune diseases, allergies and infectious diseases. Many modern therapies involve the adaptive immune system, which has developed a wide range of immune receptors to recognise and remove pathogens and cancer cells. The sequence-data sets characterising this adaptive immune receptor repertoire (AIRR-seq) could revolutionise vaccine research and the development of therapies against autoimmune diseases and cancer. iReceptor Plus aims to advance the understanding of immune responses, and thus provide new targets for therapies and new methods for monitoring therapeutic efficacy. It offers a new class of biomarkers to support novel treatments, the ability to share and compare AIRR-seq data and promote the discovery of biomedical interventions that manipulate the adaptive immune system such as vaccines and other immunotherapies.

Acronym

iReceptor+

Responsible

Artur Jorge da Silva Rocha

Status

Closed

Start

January 1, 2019

End

January 31, 2022

Effective End

January 31, 2022

Global Budget

€7,856,925.00

Financing

€877,292.50

Website

Members

Team Leaders

Artur Rocha

He is a senior researcher at INESC TEC since 1998. He is coordinator of HumanISE - Human-centered computing and Information Science

Current research interests include platforms and methods for collaborative research, privacy-preserving distributed computation, the semantic sensor Web (IoT) and Big Data processing.

From October 1996 to December 1997, he was an associate member of CERN - European Laboratory for High Energy Physics, IT Division/Web Office.

His research is applied in two major areas: Personalized Health Research (PHR) and Earth and Ocean Observation Science (EOOS).

The PHR area currently subdivides in: a) personalized Internet-based treatments; and b) human data storage, privacy-preserving processing and controlled FAIR data sharing. In this area, he participates in several European projects, such as ICT4Depression (FP7), E-COMPARED (FP7), STOP Depression (EEA Grant), iCare4Depression (FCT), RECAP Preterm (H2020), EUCAN-Connect (H2020) and iReceptor Plus (H2020). In these projects, he often undertakes the role of responsible for the system's architecture, platform implementation, or technical coordinator.

In the EOOS area he participates in the implementation of the RAIA Observatory (Interreg projects RAIA, RAIA.co, RAIA TEC, MarRisk and RADAR ON RAIA), SeaBioData(EEA Grant), MELOA (H2020) and C4G which is the Portuguese node of EPOS (H2020 EPOS-SP).

Team Members

Hugo Sereno Ferreira

Filipe Figueiredo Correia

Dinis Filipe Trigo

Ademar Aguiar

Alexandre Carvalho

Alexandre Almeida Costa

Artur Rocha

João Correia Lopes

Marco Amaro Oliveira

Disseminations

INESC TEC has a unique and differentiating management model, improved over its 35 years of history. Reflecting its unique position between academia and industry, the management at INESC TEC carefully balances, in a hybrid model, the academic culture of scientific freedom and dialogue with a culture of efficiency and responsibility in management.

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Associated Centres

Human-Centered Computing and Information Science

The Centre for Human-Centered Computing and Information Science (HumanISE) brings together engineers, scientists, and designers with expertise in Human-Centred Computing (HCC), Computer Science (CS), and Information Science (IS). Interdisciplinarity, one of the Centre’s defining features, fosters the development of software systems, methods, and tools designed to empower individuals and their communities. The excellence and impact of HumanISE’s research, innovation, and consultancy activities allow addressing increasingly complex, volatile, heterogeneous, ambiguous, and uncertain challenges, while ensuring compliance with legal, ethical, and organisational standards and frameworks. Value transfer is achieved through close collaboration with academia and industry partners. HumanISE’s core research areas include Human-Computer Interaction; Computer Graphics and Interactive Digital Media; Information Management and Information Systems; Software Engineering; and Large-Scale and Special-Purpose Computing Systems, Languages, and Tools; as well as Computing for Embedded and Cyber-Physical Systems. HumanISE also explores innovation domains like Earth, Ocean and Space Sciences; Personalised Health Research; Geospatial Information Systems Engineering; and Applied Information Systems and Computing.